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KMID : 0191120140290030456
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Journal of Korean Medical Science
2014 Volume.29 No. 3 p.456 ~ p.459
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Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
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Jang Dai-Ho
Yoon Cheol-Hee
Choi Byeong-Sun
Chung Yoon-Seok
Kim Hye-Young
Chi Sung-Gil
Kim Sung-Soon
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Abstract
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HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and susceptibility to the fusion inhibitor T-20. Therefore, we analyzed the natural polymorphism of gp41 of 163 HIV-1 isolates from T-20-naive Koreans infected with HIV-1. This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries. Minor T-20 resistance mutations such as L45M (1.2%), N126K (1.2%), and E137K (6.7%) were detected, but the critical T-20 resistance mutations were not detected in the gp41 HR1 and HR2 regions. In addition, the N42S mutation (12.9%) associated with T-20 hypersusceptibility was detected at a high frequency. These results may serve as useful data for studies considering T-20 for use in the development of a more effective anti-retroviral treatment in Korea.
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KEYWORD
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Fusion Inhibitor, Fusion Peptide, Gp41 Polymorphism, HIV-1 Envelope Glycoprotein, T-20 Resistance Mutation
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